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KMID : 1161420140170050527
Journal of Medicinal Food
2014 Volume.17 No. 5 p.527 ~ p.534
The Protective Effect of Dietary Arthrospira (Spirulina) maxima Against Mutagenicity Induced by Benzo[alpha]pyrene in Mice
Chamorro-Cevallos German A.

Garduno-Siciliano Leticia
Martinez-Galero Elizdath
Mojica-Villegas Angelica
Pages Nicole
Gutierrez-Salmean Gabriela
Abstract
Benzo[alpha]pyrene (B[¥á]P) was used to test the possible antimutagenic effects of Arthrospira (Spirulina) maxima (SP) on male and female mice. SP was orally administered at 0, 200, 400, or 800?mg/kg of body weight to animals of both sexes for 2 weeks before starting the B[¥á]P (intraperitoneal injection) at 125?mg/kg of body weight for 5 consecutive days. For the male dominant lethal test, each male was caged with two untreated females per week for 3 weeks. For the female dominant lethal test, each female was caged for 1 week with one untreated male. All the females were evaluated 13?15 days after mating for incidence of pregnancy, total corpora lutea, total implants and pre- and postimplant losses. SP protected from B[¥á]P-induced pre- and postimplant losses in the male dominant lethal test, and from B[¥á]P-induced postimplantation losses in treated females. Moreover, SP treatment significantly reduced the detrimental effect of B[¥á]P on the quality of mouse semen. Our results illustrate the protective effects of SP in relation to B[¥á]P-induced genetic damage to germ cells. We conclude that SP, owing mainly to the presence of phycocyanin, could be of potential clinical interest in cancer treatment or prevention of relapse.
KEYWORD
anticancer, antigenotoxic, antioxidant, blue-green algae, cyanobacterium
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