KMID : 1161420140170050527
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Journal of Medicinal Food 2014 Volume.17 No. 5 p.527 ~ p.534
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The Protective Effect of Dietary Arthrospira (Spirulina) maxima Against Mutagenicity Induced by Benzo[alpha]pyrene in Mice
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Chamorro-Cevallos German A.
Garduno-Siciliano Leticia Martinez-Galero Elizdath Mojica-Villegas Angelica Pages Nicole Gutierrez-Salmean Gabriela
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Abstract
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Benzo[alpha]pyrene (B[¥á]P) was used to test the possible antimutagenic effects of Arthrospira (Spirulina) maxima (SP) on male and female mice. SP was orally administered at 0, 200, 400, or 800?mg/kg of body weight to animals of both sexes for 2 weeks before starting the B[¥á]P (intraperitoneal injection) at 125?mg/kg of body weight for 5 consecutive days. For the male dominant lethal test, each male was caged with two untreated females per week for 3 weeks. For the female dominant lethal test, each female was caged for 1 week with one untreated male. All the females were evaluated 13?15 days after mating for incidence of pregnancy, total corpora lutea, total implants and pre- and postimplant losses. SP protected from B[¥á]P-induced pre- and postimplant losses in the male dominant lethal test, and from B[¥á]P-induced postimplantation losses in treated females. Moreover, SP treatment significantly reduced the detrimental effect of B[¥á]P on the quality of mouse semen. Our results illustrate the protective effects of SP in relation to B[¥á]P-induced genetic damage to germ cells. We conclude that SP, owing mainly to the presence of phycocyanin, could be of potential clinical interest in cancer treatment or prevention of relapse.
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KEYWORD
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anticancer, antigenotoxic, antioxidant, blue-green algae, cyanobacterium
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